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1. Will there be a cure for spinal cord injury?• The answer to this question of course depend on one's definition of a cure. If a cure means eradication of spinal cord injury, I think that it is unlikely in my lifetime. If a cure means complete restoration of all function to "normal" or pre-injury levels for all people with spinal cord injury, I think that that this is unlikely because we probably will not have therapies that can completely reverse aging and changes of the body due to the injury. On the other hand, I believe that there will be effective therapies that will restore function to people with spinal cord injury, including touch and pain sensations, bladder and bowel function, erection and ejaculation, and motor control including long-distance walking. Several years ago, I tried to get around the problem of the definition of "cure" by proposing that a person would be cured if a well-informed observer cannot tell that a person has had spinal cord injury. This does not necessarily mean that the person has been completely restored to pre-injury levels or all functions are normal. 2. When will a cure be available?• Some therapies are restoring substantial function to some people. These are what I call the first generation therapies which include treatments like weight-supported treadmill ambulation training, decompression and untethering of a spinal cord that is compressed. Some preliminary data suggest that certain cell transplants such as olfactory ensheathing glia transplants will restore 4-8 levels of sensory function and 1-2 levels of motor function. None of these therapies can be construed as a cure. Second generation therapies are beginning to come into clinical trial and should be available in a few years. These include nasal mucosa olfactory ensheathing glia, Schwann cell transplants, and perhaps even embryonic stem cells. The latter unfortunately have been mired in political debate and has already been delayed by 4 years. In addition, several therapies such as Nogo receptor blockers and Nogo antibodies, glial-derived neurotrophic factor, chondroitinase, and other treatments are being developed for clinical trial and may come on line within a year or two. The timing of such treatments depends on the availability of funding for clinical trials. But, if sufficient funding were available, I think that some of these treatments will be shown to be effective and will be available in 4 years. Finally, third generation therapies will be closer to the "cure". These include possible combination cell transplant therapies with growth factors and other treatments that stimulate regeneration of the spinal cord. These should produce more recovery in more people. For example, cell transplants combined with drugs such as glial-derived neurotrophic factor, chondroitinase ABC, and cAMP/rolipram have been reported to produce significantly better regeneration in rats compared to individual treatments. The rate at which these treatments get into clinical trial depend on the amount of funding available for clinical trial. If funding were made available, I think that some of third generation therapies will be available as soon as 8 years from now.
Les périodes les plus courtes possibles pour des résultats pivot pour SCI Chronique :2002 Formation de tapis roulant2003 SR de Fampridine Lokomat et d'autres dispositifs2004 Stimulation L2 lombaire Pont périphérique en nerf de SCI2005 Courant électrique à C.A. Copaxone Pont périphérique pour la vessie Inosine2006 AIT-082 Rolipram Dresseurs de récepteur de Nogo Humain foetal OEGCellules de tige humaines foetalesAnticorps M12007 ChondroitinaseOEG PorcinAdulte OEG humainCellules de tige humaines d'adulteCellules de tige neurales d'adulte2008 C3 de recombinaisonVaccin thérapeutique IN-1Vaccin thérapeutiqueCellule transplant+AIT-082Cellule transplant + CopaxoneCellule transplant + inosineCellule transplant + neurotrophinCellule transplant + rolipramDresseur des cellules transplant + Nogo2009 C3 de recombinaisonCellule transplant+chondroitinase2010 Vaccin des cellules transplant+therCellule transplant+IN-12011 Cellule transplant+C32012 Cellules souches embryonnaires
Apparemment j'ai du toucher un point sensible, au vu des réactions...mais bref, la prochaine fois j'applaudirai, le sourire béat, la langue dehors
afin de ne pas décevoir les espoirs et d'oser émettre un avis sur un interview que je trouvais somme toute moins optimiste que toutes les infos habituelles qui paraissent dans cette rubrique.
Mis à part ça si à chaque fois qu'une critique est émise, Nico et Thierry, vous pensez que votre travail est remis en question... :? suis désolé de votre manque de confiance en vous.
méfiez-vous des commentaires pessimistes, Thierry le modérateur n'est pas très tolérant
Quant à moi, je préfère centrer mon énergie sur ce qui est bien présent: les fonctions qui me restent. Et je crois que je n'en profite encore pas assez, va falloir que que je mette les bouchées doubles
perso j'y ai répondu il y a qques jours dans "essais pré-cliniques..." interview de Wise Young : http://www.asso-alarme.com/forum/ftopic453.phpje persiste et signe, mais méfiez-vous des commentaires pessimistes, Thierry le modérateur n'est pas très tolérant