Auteur Sujet: gènes PTEN et SOCS3 favorisent la régénération axonale  (Lu 2592 fois)

0 Membres et 1 Invité sur ce sujet

Hors ligne Renaud

  • Membre de l'association
  • Intermitent du forum
  • ******
  • Messages: 33
  • Sexe: Homme
    • Voir le profil
gènes PTEN et SOCS3 favorisent la régénération axonale
« Réponse #1 le: 18 janvier 2012 à 15:30:25 »
Bonjour à tous,
 
le Miami Project à publié une étude signicatives principalement sur la suppression de 2 gênes PTEN et SOCS3, favorisant une régénération axonale soutenue et sur de longue distance à la suite d'une lésion sur l système nerveux centrale.
Le Miami Project espère transcrire cette découverte vers l'essais clinique dans un future proche.
 
L'article est en anglais si une personne à le temps de le traduire:
 
 
THE MIAMI PROJECT RESEARCHER CO-AUTHORS MANUSCRIPT PUBLISHED IN NATURE JOURNAL
Miami Project researcher, Dr. Kevin Park, and colleagues, published a manuscript in the December 15th issue of the preeminent journal Nature, that demonstrates the deletion of two genes, phosphatase and tensin homologue (PTEN) and suppressor of cytokine signaling 3 (SOCS3), which are highly expressed in the injured central nervous system (CNS) neurons, promotes continued and significant long-tract regeneration following CNS injury.
 
The study, conducted with colleagues at F.M. Kirby Neurobiology Center, Children's Hospital Boston, and Harvard Medical School, and led by Dr. Zhigang He, was conducted on damaged optic nerves, which are part of the CNS.  These findings may ultimately provide an important avenue to researchers currently unraveling the mysteries of spinal cord injury (SCI) and other neurodegenerative disorders since long distance axonal regeneration has, until this point, proved difficult to attain.  It is widely felt among experts that long distance regeneration is an essential component to functional recovery following CNS injury, which is why these results are exciting to neuroscientists.
 
“This is truly an exciting time in paralysis and CNS injury research.  Each day we are answering more questions that provide us another piece of the puzzle,” said Miami Project Scientific Director, Dr. W. Dalton Dietrich.  “As our researchers continue to obtain more critical information, viable solutions and strategies for ultimately treating paralysis come into clearer view.  We hope to then move these promising therapies for testing in the clinic in the near future.”
 
Axons of the mammalian CNS typically do not regenerate after injury. Developing a strategy to promote regeneration and functional reconnection of injured CNS axons has been a long standing challenge, and central to The Miami Project to Cure Paralysis’ mission. This study demonstrated for the first time that simultaneous removal of both the PTEN and SOCS3 genes, which are highly expressed in injured neurons, allows sustained and robust long distance axon regeneration in the optic nerve after injury.  In addition, this study showed that double deletion of these genes works synergistically to regulate activation and expression of several growth-related genes that improve axon regeneration. Stemming from this finding, future work in this area will be directed at examining whether the regenerated axons after PTEN/SOCS3 deletion can reform synapses and restore behavioral functions.
 
Injury to the CNS has devastating effects on the structure and function of the brain and spinal cord.  Since the early 1980s, immense research progress has been made and has given hope that injuries to the CNS will one day be repairable. Still, there is much that researchers need to learn about the complex processes that occur in the brain and spinal cord after injury, and how those processes can be changed or reversed.
 
Miami Project investigators daily are conducting a broad scope of research to address the consequences of these neurological injuries. Our work is directed at the following areas: understanding what happens after CNS injury; protecting the injured brain and spinal cord from further damage, replacing dead nervous system cells (neurons and glia), promoting and guiding axon growth, reestablishing essential circuitry, preventing and treating complications, maintaining maximum potential for recovery, and ultimately translating our findings from laboratory research to clinical trials.
 



 

Utilisateur

 
 
Bienvenue, Invité. Merci de vous connecter ou de vous inscrire.

Soutenez-nous

Recherche rapide


* Sujet récents

vessie, sonde, stent par Ludvig
[24 mars 2024 à 11:12:53]


vessie, sonde, stent par addidia
[23 mars 2024 à 20:44:33]


vessie, sonde, stent par Ludvig
[23 mars 2024 à 19:30:49]


vessie, sonde, stent par addidia
[23 mars 2024 à 16:40:55]


Fauteuils roulants : un remboursement à 100 % pour 2024 par RosenKreutz
[23 mars 2024 à 15:43:38]


Fauteuils roulants : un remboursement à 100 % pour 2024 par Frog2Lille
[23 mars 2024 à 15:34:10]


vessie, sonde, stent par Ludvig
[23 mars 2024 à 11:13:35]


vessie, sonde, stent par addidia
[22 mars 2024 à 20:28:57]


Implantation prothèse pénienne par tetra4
[17 mars 2024 à 14:53:11]


Implantation prothèse pénienne par misterjp
[17 mars 2024 à 12:33:41]

* Qui est en ligne

* Derniers Membres

Lavandula2
90j 22h 24m
chris26 chris26
84j 2h 18m
Arnaud Arnaud
83j 9h 36m
charlieboy charlieboy
66j 4h 19m
Gyzmo34 Gyzmo34
63j 9m

* Top membres

gilles gilles
5045 Messages
TDelrieu TDelrieu
4070 Messages
anneso
1872 Messages
farid
1320 Messages
caro23 caro23
1269 Messages
Lavandula2
1268 Messages
J.Solis J.Solis
995 Messages
SMF spam blocked by CleanTalk